Title: BV2 / BV2 - 2 / Modul 5 / The electron transport chain

Q: What is oxidative phsophorylation (OXPHOS)?
A: Oxidative phosphorylation describes the process of linking the oxidation of the electron carriers NADH and FADH2 in the respiratory chain to the synthesis of ATP by an ATP synthase

Q: What do complexes I-IV do in the ETC?
A: 4 complexes (complexes I-IV) within the inner mitochondrial membrane transfer electrons from NADH and FADH2 to molecular oxygen, forming H2O
- Together, they therefore form a respiratory chain

Q: What can be said about the reaction of complexes I-IV?
A: This reaction is highly exergenic

Q: What is the energy released from the reactions in complexes 1-4 in the ETC used for?
A: This reaction is highly exogenic and the energy released is used to pump hydrogen ions (H+) across the inner mitochondrial membrane into the intermembrane space.

Q: What does the pumping of H+ across the inner mitochondrial membrane generate?
A: Membrane potential/electrical gradient

Q: What is the re-entering of H+ into the matrix used by (electrochemical gradient form it)?
A: It's used by an ATP synthase (complex V) to synthesis ATP from ADP
and monophosphate (Pi)

Q: From what does complex V synthesize ATP from?
A: ADP and monophosphate (Pi)

Q: What is another name for oxidative phosphorylation or the ETC?
A: Chemiosmosis

Q: What is the study of OXPHOS called?
A: Bioenergetics

Q: What are respiration and ATP synthesis?
A: Respiration and ATP synthesis are coupled

Q: What is the overall reaction of OXPHOS from NADH?
A: NADH + 3 ADP + 3Pi + ½ O2 + H+ → NAD+ + 3 ATP + H2O